Cytidine Deaminase (CDA)
CDD; Cytidine aminohydrolase
Cytidine deaminase forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
Kuhn et al. (1993) identified a cDNA clone corresponding to the human CDA gene in a study of expression products related to monocyte and macrophage differentiation. The deduced 145-residue protein has a molecular mass of 16.1 kD and shows nearly 50% homology to cytidine deaminase from Bacillus subtilis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Hu01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Hu01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Hu01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Hu01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Hu01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Mu01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Mu01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Mu01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Mu01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Mu01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Ra01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Ra01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Ra01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Ra01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Ra01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Ca01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Ca01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Ca01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Ca01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Ca01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Po01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Po01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Po01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Po01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Po01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Bo01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Bo01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Bo01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Bo01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Bo01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Rb01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Rb01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Rb01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Rb01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Rb01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU482Mo01 | Recombinant Cytidine Deaminase (CDA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU482Mo01 | Monoclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IP. |
| PAU482Mo01 | Polyclonal Antibody to Cytidine Deaminase (CDA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU482Mo01 | CLIA Kit for Cytidine Deaminase (CDA) | CLIA assay for Antigen Detection |
| ELU482Mo01 | ELISA Kit for Cytidine Deaminase (CDA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA."
Cancer Res. 54:5401-5407(1994) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of the gene coding for human cytidine deaminase."
Biochim. Biophys. Acta 1443:323-333(1998) [PubMed] [Europe PMC] [Abstract]
"Growth inhibition of granulocyte-macrophage colony forming cells by human cytidine deaminase requires the catalytic function of the protein."
Blood 91:4127-4135(1998) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation."
Biochem. Biophys. Res. Commun. 190:1-7(1993) [PubMed] [Europe PMC] [Abstract]
"Structure of human cytidine deaminase bound to a potent inhibitor."
J. Med. Chem. 48:658-660(2005) [PubMed] [Europe PMC] [Abstract]