Corneodesmosin (CDSN)
HTSS; S protein
Corneodesmosin is a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
Corneodesmosomes are intercellular structures that are involved in desquamation, the shedding of superficial corneocytes from the skin surface. Corneocytes are anucleated cells derived from keratinocytes during the late stages of terminal differentiation of cornified squamous epithelia such as the epidermis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U479Hu01 | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | MU479Hu22 | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| PU479Hu01 | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU479Hu | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Corneodesmosin (CDSN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Corneodesmosin (CDSN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Corneodesmosin (CDSN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Corneodesmosin (CDSN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Corneodesmosin (CDSN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Corneodesmosin (CDSN) | CLIA assay for Antigen Detection |
Reference
"Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation."
Proc. Natl. Acad. Sci. U.S.A. 90:9470-9474(1993) [PubMed] [Europe PMC] [Abstract]
"Expression cloning of human corneodesmosin proves its identity with the product of the S gene and allows improved characterization of its processing during keratinocyte differentiation."
J. Biol. Chem. 273:22640-22647(1998) [PubMed] [Europe PMC] [Abstract]
"Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis."
Tissue Antigens 60:77-83(2002) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of six novel polymorphisms in the human corneodesmosin gene."
Tissue Antigens 57:32-38(2001) [PubMed] [Europe PMC] [Abstract]
"Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris."
Tissue Antigens 54:439-449(1999) [PubMed] [Europe PMC] [Abstract]
"Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes."
J. Biol. Chem. 272:31770-31776(1997) [PubMed] [Europe PMC] [Abstract]
"Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin."
Nat. Genet. 34:151-153(2003) [PubMed] [Europe PMC] [Abstract]
"Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: unraveling the peeling skin disease."
Am. J. Hum. Genet. 87:274-281(2010) [PubMed] [Europe PMC] [Abstract]
"S gene (Corneodesmosin) diversity and its relationship to psoriasis; high content of cSNP in the HLA-linked S gene."
J. Invest. Dermatol. 114:1158-1163(2000) [PubMed] [Europe PMC] [Abstract]
"Psoriasis is associated with a SNP haplotype of the corneodesmosin gene (CDSN)."
Tissue Antigens 60:292-298(2002) [PubMed] [Europe PMC] [Abstract]