Chloride Intracellular Channel Protein 1 (CLIC1)

G6; NCC27; p64CLCP; hRNCC; Chloride channel ABP; Nuclear chloride ion channel 27; Regulatory nuclear chloride ion channel protein

SPN	U458
HGNC	2062
MGI	2148924
PubMed	22956539
RGD	1303043
UniProt	O00299
Wiki	CLIC1

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel protein 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.

Reference

"Molecular cloning and expression of a chloride ion channel of cell nuclei."
J. Biol. Chem. 272:12575-12582(1997) [PubMed] [Europe PMC] [Abstract]

"A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons."
J. Neurosci. 19:2919-2928(1999) [PubMed] [Europe PMC] [Abstract]

"Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region."
J. Immunol. 163:278-287(1999) [PubMed] [Europe PMC] [Abstract]

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]