Complexin 1 (CPLX1)

CPX-I; CPX1; Synaphin-2

SPN	U449
HGNC	2309
MGI	104727
PubMed	17652102
RGD	70944
UniProt	O14810
Wiki	CPLX1

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. Complexin-1 binds to the SNAP receptor complex and disrupts it, allowing transmitter release. The highly specialized uptake and exocytosis system of synaptic vesicle traffic has been studied extensively as a model of membrane fusion. The fusion reaction begins with the assembly of a core complex consisting of the plasma membrane proteins syntaxin and SNAP25 and the synaptic vesicle protein synaptobrevin. The core complex then serves as a soluble NSF attachment protein receptor, or SNARE. Binding of SNAP to SNARE leads to ATP-dependent binding of NSF, which subsequently catalyzes disruption of the SNARE complex.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Hu01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Hu01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Hu01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Hu01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Hu01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Mu01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Mu01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Mu01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Mu01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Mu01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Ra01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Ra01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Ra01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Ra01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Ra01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Ca01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Ca01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Ca01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Ca01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Ca01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Po01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Po01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Po01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Po01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Po01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Bo01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Bo01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Bo01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Bo01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Bo01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Rb01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Rb01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Rb01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Rb01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Rb01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU449Mo01	Recombinant Complexin 1 (CPLX1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU449Mo01	Monoclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IP.
Antibodies	PAU449Mo01	Polyclonal Antibody to Complexin 1 (CPLX1)	WB; IHC; ICC; IF.
Assay Kits	CLU449Mo01	CLIA Kit for Complexin 1 (CPLX1)	CLIA assay for Antigen Detection
Assay Kits	ELU449Mo01	ELISA Kit for Complexin 1 (CPLX1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complexins: cytosolic proteins that regulate SNAP receptor function."
Cell 83:111-119(1995) [PubMed] [Europe PMC] [Abstract]

"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia."
Lancet 352:1669-1673(1998) [PubMed] [Europe PMC] [Abstract]

"Cerebellar synaptic protein expression in schizophrenia."
Neuroscience 105:219-229(2001) [PubMed] [Europe PMC] [Abstract]

"Proteome analysis of human substantia nigra in Parkinson's disease."
Proteomics 4:3943-3952(2004) [PubMed] [Europe PMC] [Abstract]

"Complexin cross-links prefusion SNAREs into a zigzag array."
Nat. Struct. Mol. Biol. 18:927-933(2011) [PubMed] [Europe PMC] [Abstract]