Cisplatin Resistance Associated Overexpressed Protein (CROP)

LUC7L3; LUC7A; CREAP-1; CRA; CRE-Associated Protein; Luc7-like protein 3; Okadaic acid-inducible phosphoprotein OA48-18; cAMP regulatory element-associated protein 1

SPN	U443
HGNC	24309
MGI	1914934
PubMed	16319398
RGD	1307981
UniProt	O95232
Wiki	CROP

The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). Cisplatin resistance-associated overexpressed protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.The shorter variant encodes a deduced 432-amino acid protein. The N-terminal half contains cystine/histidine motifs and leucine zipper-like repeats, and the C-terminal half consists mostly of charged and polar amino acids. The longer variant contains several nonsense codons and is not translatable.

Reference

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FEBS Lett. 465:153-156(2000) [PubMed] [Europe PMC] [Abstract]

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Biochem. Cell Biol. 84:9-19(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells."
J. Biomed. Sci. 7:152-159(2000) [PubMed] [Europe PMC] [Abstract]

"Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A."
Biochem. Biophys. Res. Commun. 301:324-329(2003) [PubMed] [Europe PMC] [Abstract]

"A novel SR-related protein is required for the second step of pre-mRNA splicing."
Mol. Cell. Biol. 25:2969-2980(2005) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection."
Mol. Cell. Biol. 28:5924-5936(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing."
Science 325:90-93(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]