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C-Terminal Binding Protein 1 (CTBP1)

BARS; Brefeldin A-Ribosylated Substrate

C-terminal-binding protein 1 is a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. transcriptional co-repressor protein that may function in development, cell cycle regulation and cellular transformation; regulates tubulation of Golgi structures upon treatment with brefeldin A; interacts wth GTP, beta gamma subunits of G-proteins and viral EBNA3A protein

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Hu01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Hu01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Hu01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Hu01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Hu01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Mu01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Mu01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Mu01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Mu01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Mu01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Ra01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Ra01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Ra01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Ra01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Ra01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Ca01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Ca01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Ca01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Ca01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Ca01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Po01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Po01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Po01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Po01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Po01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Bo01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Bo01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Bo01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Bo01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Bo01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Rb01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Rb01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Rb01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Rb01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Rb01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU439Mo01 Recombinant C-Terminal Binding Protein 1 (CTBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU439Mo01 Monoclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IP.
PAU439Mo01 Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) WB; IHC; ICC; IF.
Assay Kits CLU439Mo01 CLIA Kit for C-Terminal Binding Protein 1 (CTBP1) CLIA assay for Antigen Detection
ELU439Mo01 ELISA Kit for C-Terminal Binding Protein 1 (CTBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation."
Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995) [PubMed] [Europe PMC] [Abstract]

"C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins."
Mol. Cell. Biol. 19:777-787(1999) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis."
EMBO J. 12:469-478(1993) [PubMed] [Europe PMC] [Abstract]

"Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles."
J. Biol. Chem. 276:44936-44943(2001) [PubMed] [Europe PMC] [Abstract]

"Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C."
J. Virol. 75:7749-7755(2001) [PubMed] [Europe PMC] [Abstract]

"Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP."
Mol. Cell. Biol. 21:6181-6188(2001) [PubMed] [Europe PMC] [Abstract]

"Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP)."
J. Biol. Chem. 277:47197-47204(2002) [PubMed] [Europe PMC] [Abstract]

"The polycomb protein Pc2 is a SUMO E3."
Cell 113:127-137(2003) [PubMed] [Europe PMC] [Abstract]

"Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP."
Cell 115:177-186(2003) [PubMed] [Europe PMC] [Abstract]

"Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene."
Mol. Cell. Biol. 24:10223-10235(2004) [PubMed] [Europe PMC] [Abstract]

"Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."
Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]

"Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."
J. Biol. Chem. 280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]

"Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP."
Oncogene 24:6165-6173(2005) [PubMed] [Europe PMC] [Abstract]

"The FoxP subclass in Xenopus laevis development."
Dev. Genes Evol. 216:641-646(2006) [PubMed] [Europe PMC] [Abstract]

"Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."
J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]

"ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."
Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"CtBP is an essential corepressor for BCL6 autoregulation."
Mol. Cell. Biol. 28:2175-2186(2008) [PubMed] [Europe PMC] [Abstract]

"Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1."
Mol. Cell. Biol. 29:1321-1337(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase."
Mol. Cell 10:857-869(2002) [PubMed] [Europe PMC] [Abstract]