Cubilin (CUBN)
IFCR; MGA1; gp280; Intrinsic Factor Cobalamin Receptor; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-vitamin B12 receptor
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U437Hu01 | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | MU437Hu22 | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| PU437Hu01 | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU437Hu | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| PU437Mu01 | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| LU437Mu71 | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| LU437Mu81 | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| PU437Ra01 | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU437Ra | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cubilin (CUBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cubilin (CUBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cubilin (CUBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cubilin (CUBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cubilin (CUBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cubilin (CUBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cubilin (CUBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cubilin (CUBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cubilin (CUBN) | CLIA assay for Antigen Detection |
Reference
"The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region."
Blood 91:3593-3600(1998) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein."
Nat. Med. 5:656-661(1999) [PubMed] [Europe PMC] [Abstract]
"Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)."
Proc. Natl. Acad. Sci. U.S.A. 98:13895-13900(2001) [PubMed] [Europe PMC] [Abstract]
"Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia."
Proc. Natl. Acad. Sci. U.S.A. 98:12491-12496(2001) [PubMed] [Europe PMC] [Abstract]
"The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless."
Blood 103:1573-1579(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of the ligands of protein interaction domains through a functional approach."
Mol. Cell. Proteomics 6:333-345(2007) [PubMed] [Europe PMC] [Abstract]
"Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes."
Nature 464:445-448(2010) [PubMed] [Europe PMC] [Abstract]
"Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1."
Nat. Genet. 21:309-313(1999) [PubMed] [Europe PMC] [Abstract]
"Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin."
Blood 96:405-409(2000) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
"CUBN is a gene locus for albuminuria."
J. Am. Soc. Nephrol. 22:555-570(2011) [PubMed] [Europe PMC] [Abstract]
"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
"Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populations."
BMC Nephrol. 13:142-142(2012) [PubMed] [Europe PMC] [Abstract]