Cathelicidin Antimicrobial Peptide (CAMP)

CAP18; FALL39; HSD26; LL37; 18 kDa Cationic Antimicrobial Protein; Antibacterial protein FALL-39; FALL-39 peptide antibiotic

SPN	U429
HGNC	1472
MGI	108443
PubMed	15985530
RGD	1559878
UniProt	P49913
Wiki	Cathelicidin

Cathelicidin antimicrobial peptide is a family of polypeptides found in lysosomes in polymorphonuclear leukocytes (PMNs).Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain. Cathelicidin peptides have been isolated from many different species of mammals. Cathelicidins were originally found in neutrophils but have since been found in many other cells including epithelial cells and macrophages activated by bacteria, viruses, fungi, or the hormone 1,25-D. The cathelicidin family shares primary sequence homology with the cathepsin family of cysteine proteinase inhibitors, although amino acid residues thought to be important in such protease inhibition are usually lacking.

Reference

"FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis."
Proc. Natl. Acad. Sci. U.S.A. 92:195-199(1995) [PubMed] [Europe PMC] [Abstract]

"hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules."
FEBS Lett. 368:173-176(1995) [PubMed] [Europe PMC] [Abstract]

"Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein."
Infect. Immun. 63:1291-1297(1995) [PubMed] [Europe PMC] [Abstract]

"Structural, functional analysis and localization of the human CAP18 gene."
FEBS Lett. 398:74-80(1996) [PubMed] [Europe PMC] [Abstract]

"The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes."
Eur. J. Biochem. 238:325-332(1996) [PubMed] [Europe PMC] [Abstract]

"Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules."
Clin. Diagn. Lab. Immunol. 8:370-375(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region."
J. Am. Chem. Soc. 128:5776-5785(2006) [PubMed] [Europe PMC] [Abstract]

"Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles."
J. Biol. Chem. 283:32637-32643(2008) [PubMed] [Europe PMC] [Abstract]