Chimerin 2 (CHN2)

ARHGAP3; BCH; RHoGAP3; Chimaerin; Beta-Chimaerin; Beta-chimerin; Rho GTPase-activating protein 3

SPN	U428
HGNC	1944
MGI	1917243
PubMed	8440677
RGD	620140
UniProt	P52757
Wiki	Chimerin_2

Beta-chimaerin is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane.

The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U428Hu01	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	PU428Hu01	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U428Mu01	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	PU428Mu01	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U428Ra01	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	PU428Ra01	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Chimerin 2 (CHN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Chimerin 2 (CHN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Chimerin 2 (CHN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Chimerin 2 (CHN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Chimerin 2 (CHN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Chimerin 2 (CHN2)	CLIA assay for Antigen Detection

Reference

"Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain."
J. Biol. Chem. 269:12888-12892(1994) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma."
Cancer Res. 55:3456-3461(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin."
Cell 119:407-418(2004) [PubMed] [Europe PMC] [Abstract]