Developmental Pluripotency Associated Protein 3 (DPPA3)

STELLA; STELLAR; Stella-related protein

SPN	U415
HGNC	19199
MGI	1920958
PubMed	14684992
UniProt	Q6W0C5
Wiki	DPPA3

Developmental pluripotency-associated protein 3 is a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.

The deduced protein contains 150 amino acids. Northern blot analysis detected a 1.2-kb transcript expressed in male mouse gonads at 13.5 days postcoitum. In situ hybridization of whole mouse embryos showed Dppa3 expressed initially in the gonads of both sexes, but expression was downregulated in female gonads by at least 13.5 days postcoitum. Embryonic mice deficient in germ cells did not express Dppa3.

Reference

"Stella is a maternal effect gene required for normal early development in mice."
Curr. Biol. 13:2110-2117(2003) [PubMed] [Europe PMC] [Abstract]

"Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma."
Stem Cells 22:169-179(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"NANOS3 function in human germ cell development."
Hum. Mol. Genet. 20:2238-2250(2011) [PubMed] [Europe PMC] [Abstract]

"Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours."
Cytogenet. Genome Res. 101:261-265(2003) [PubMed] [Europe PMC] [Abstract]