Deoxycytidine Kinase (DCK)

SPN	U408
HGNC	2704
MGI	102726
PubMed	1406603
RGD	620667
UniProt	P27707
Wiki	DCK

Deoxycytidine kinase (DCK)is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is clinically important because of its relationship to drug resistance and sensitivity. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.Human deoxyribonucleoside kinases are required for the pharmacologic activity of several clinically important anticancer and antiviral nucleoside analogs.

Reference

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"Human deoxycytidine kinase is located in the cell nucleus."
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"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

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Biochemistry 49:6784-6790(2010) [PubMed] [Europe PMC] [Abstract]

"The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues."
J. Med. Chem. 53:5792-5800(2010) [PubMed] [Europe PMC] [Abstract]