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Endosulfine Alpha (ENSa)

ENS-A; ARPP-19e

Alpha-endosulfine belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U389Mu01 Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
PU389Mu01 Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits KEU389Mu ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Endosulfine Alpha (ENSa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Endosulfine Alpha (ENSa) Bioactivity
Antibodies NONE Monoclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Endosulfine Alpha (ENSa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Endosulfine Alpha (ENSa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Endosulfine Alpha (ENSa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Endosulfine Alpha (ENSa) CLIA assay for Antigen Detection

Reference

"Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties."
Proc. Natl. Acad. Sci. U.S.A. 95:8387-8391(1998) [PubMed] [Europe PMC] [Abstract]

"Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels."
Diabetes 48:1873-1876(1999) [PubMed] [Europe PMC] [Abstract]

"The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians."
Mol. Genet. Metab. 81:16-21(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy."
J. Biol. Chem. 282:34555-34567(2007) [PubMed] [Europe PMC] [Abstract]

"Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha."
Biochemistry 47:12357-12364(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]