Endoplasmic Reticulum Protein 29 (ERP29)

C12orf8; ERp28; ERp31; PDI-DB; PDIA9; Protein Disulfide Isomerase Family A,Member 9

SPN	U387
HGNC	13799
MGI	1914647
PubMed	16246730
RGD	619781
UniProt	P30040
Wiki	ERp29

Endoplasmic reticulum protein 29 (ERp29) is a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

Reference

"ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif."
Eur. J. Biochem. 255:570-579(1998) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human liver protein map: update 1993."
Electrophoresis 14:1216-1222(1993) [PubMed] [Europe PMC] [Abstract]

"Human liver protein map: a reference database established by microsequencing and gel comparison."
Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB