CCAAT/Enhancer Binding Protein Delta (CEBPd)

CEBP-D; C/EBP-delta; CELF; CRP3; NF-IL6-beta; Nuclear factor NF-IL6-beta

SPN	U386
HGNC	1835
MGI	103573
PubMed	21980073
RGD	2328
UniProt	P49716
Wiki	CEBPD

CCAAT/enhancer-binding protein delta is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha.

C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.

Reference

"A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6."
Proc. Natl. Acad. Sci. U.S.A. 89:1473-1476(1992) [PubMed] [Europe PMC] [Abstract]

"The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization."
Genomics 16:520-523(1993) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene."
Nucleic Acids Res. 34:217-231(2006) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]