Endothelin 3 (EDN3)
ET3; PPET3; Preproendothelin-3
Endothelin-3 is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U383Ra01 | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| PU383Ra01 | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Endothelin 3 (EDN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Endothelin 3 (EDN3) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Endothelin 3 (EDN3) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Endothelin 3 (EDN3) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Endothelin 3 (EDN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Endothelin 3 (EDN3) | CLIA assay for Antigen Detection |
Reference
"cDNA cloning and chromosomal assignment of the gene encoding endothelin 3."
J. Biol. Chem. 264:18156-18161(1989) [PubMed] [Europe PMC] [Abstract]
"One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta."
FEBS Lett. 261:327-330(1990) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Proteolytic processing of big endothelin-3 by the kell blood group protein."
Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
"Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
"Solution structure of endothelin-3 determined using NMR spectroscopy."
Biochemistry 31:5640-5645(1992) [PubMed] [Europe PMC] [Abstract]
"Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype."
Eur. J. Hum. Genet. 5:180-185(1997) [PubMed] [Europe PMC] [Abstract]
"A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)."
Nat. Genet. 12:445-447(1996) [PubMed] [Europe PMC] [Abstract]
"Endothelin-3 frameshift mutation in congenital central hypoventilation syndrome."
Nat. Genet. 13:395-396(1996) [PubMed] [Europe PMC] [Abstract]
"Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease."
Eur. J. Hum. Genet. 5:247-251(1997) [PubMed] [Europe PMC] [Abstract]
"A heterozygous endothelin 3 mutation in Waardenburg-Hirschsprung disease: is there a dosage effect of EDN3/EDNRB gene mutations on neurocristopathy phenotypes?"
J. Med. Genet. 38:205-209(2001) [PubMed] [Europe PMC] [Abstract]
"SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism."
Hum. Genet. 111:198-206(2002) [PubMed] [Europe PMC] [Abstract]