Fatty Acid Desaturase 1 (FADS1)

D5D; FADS6; FADSD5; LLCDL1; TU12; Delta-5 Desaturase; Delta(5) fatty acid desaturase

SPN	U380
HGNC	3574
MGI	1923517
PubMed	23396965
RGD	621678
UniProt	O60427
Wiki	FADS1

Fatty acid desaturase 1 is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain.

FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Reference

"Cloning, expression, and fatty acid regulation of the human Delta-5 desaturase."
J. Biol. Chem. 274:37335-37339(1999) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid."
Biochem. J. 347:719-724(2000) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family."
Genomics 66:175-183(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids."
J. Lipid Res. 53:1502-1512(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]