Fibrinogen Gamma (FGg)

FG-G

SPN	U371
HGNC	3694
MGI	95526
PubMed	6713100
RGD	2613
UniProt	P02679
Wiki	FGG

Fibrinogen gamma chain is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots.

In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

Reference

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"Fibrinogen Nagoya, a replacement of glutamine-329 by arginine in the gamma-chain that impairs the polymerization of fibrin monomer."
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"An apparently higher molecular weight gamma-chain variant in a new congenital abnormal fibrinogen Tochigi characterized by the replacement of gamma arginine-275 by cysteine."
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"A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization."
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"Three abnormal fibrinogen variants with the same amino acid substitution (gamma 275 Arg-->His): fibrinogens Bergamo II, Essen and Perugia."
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"Normal plasmic cleavage of the gamma-chain variant of 'fibrinogen Saga' with an Arg-275 to His substitution."
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Erratum
Nat. Genet. 23:373-373(1999)

"Fibrinogen Hillsborough: a novel gamma-gly309asp dysfibrinogen with impaired clotting."
Blood 99:3597-3601(2002) [PubMed] [Europe PMC] [Abstract]

"Fibrinogen Philadelphia, a hypodysfibrinogenemia characterized by abnormal polymerization and fibrinogen hypercatabolism due to gamma S378P mutation."
Blood 105:3162-3168(2005) [PubMed] [Europe PMC] [Abstract]

"Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency."
Thromb. Haemost. 113:567-576(2015) [PubMed] [Europe PMC] [Abstract]