Follicular Lymphoma Variant Translocation 1 (FVT1)

KDSR; DHSR; SDR35C1; 3-Ketodihydrosphingosine Reductase; 3-Dehydrosphinganine reductase; Short Chain Dehydrogenase/Reductase Family 35C,Member 1

SPN	U361
HGNC	4021
MGI	1918000
PubMed	19141869
RGD	1307775
UniProt	Q06136
Wiki	FVT1

Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue. FVT1 shows a high rate of transcription in some T-cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.Sphingolipids are essential lipid components of the plasma membrane. Together with cholesterol, sphingolipids form lipid microdomains or rafts that are involved in membrane traffic and cell signaling. Synthesis of sphingolipids initiates with condensation of L-serine with palmitoyl-CoA, producing 3-ketodihydrosphingosine (KDS), followed by reduction to dihydrosphingosine by KDS reductases, like FVT1 (Kihara and Igarashi, 2004).

Reference

"FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma."
Blood 81:136-142(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 18."
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane."
J. Biol. Chem. 279:49243-49250(2004) [PubMed] [Europe PMC] [Abstract]