Fibrillarin (FBL)

FIB; FLRN; RNU3IP1; rRNA 2'-O-Methyltransferase Fibrillarin; 34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase

SPN	U358
HGNC	3599
MGI	95486
PubMed	10829025
RGD	1305542
UniProt	P22087
Wiki	Fibrillarin

Fibrillarin, also known as FBL product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing pre-ribosomal (r)RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species.
Fibrillarin is a component of several ribonucleoproteins including a nucleolar small nuclear ribonucleoprotein (SnRNP) and one of the two classes of small nucleolar ribonucleoproteins (snoRNPs). SnRNAs function in RNA splicing while snoRNPs function in ribosomal RNA processing.

Reference

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"An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs."
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"The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase."
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"The crystal structure of human fibrillarin in complex with SAH."
Submitted (FEB-2009) to the PDB data bank