Friend Leukemia Virus Integration 1 (FLI1)

EWSR2; SIC1; Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB

SPN	U356
HGNC	3749
MGI	95554
PubMed	15565546
RGD	1309837
UniProt	Q01543
Wiki	FLI1

Friend leukemia virus integration 1 is memeber of ETS transcription factor that first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F-MuLV). Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.

The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation.

Reference

"Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours."
Nature 359:162-165(1992) [PubMed] [Europe PMC] [Abstract]

"The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors."
Cell Growth Differ. 3:705-713(1992) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of human Fli-1 gene."
Cancer Res. 52:5833-5837(1992) [PubMed] [Europe PMC] [Abstract]

"Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma."
Biochim. Biophys. Acta 1172:155-158(1993) [PubMed] [Europe PMC] [Abstract]

"The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24."
Genomics 11:223-224(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Chromosome translocation based on illegitimate recombination in human tumors."
Proc. Natl. Acad. Sci. U.S.A. 95:11786-11791(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma."
Genes Chromosomes Cancer 13:126-132(1995) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the ets domain of Fli-1 when bound to DNA."
Nat. Struct. Biol. 1:871-875(1994) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the SAM_pnt-domain of the human Friend leukemia integration 1 transcription factor."
Submitted (NOV-2005) to the PDB data bank