Furin (FUR)
PACE; PCSK3; SPC1; Paired Basic Amino Acid Cleaving Enzyme; Dibasic-processing enzyme
Furin is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. A furin-like pro-protein convertase has been implicated in the processing of RGMc (also called hemojuvelin ), a gene involved in a severe iron-overload disorder called juvenile hemochromatosis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U354Hu01 | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | MU354Hu22 | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| PU354Hu01 | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| LU354Hu71 | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU354Hu | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U354Mu01 | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| PU354Mu01 | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| LU354Mu71 | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U354Ra01 | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | MU354Ra21 | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| PU354Ra01 | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU354Ra | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Furin (FUR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Furin (FUR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Furin (FUR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Furin (FUR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Furin (FUR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Furin (FUR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Furin (FUR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Furin (FUR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Furin (FUR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Furin (FUR) | CLIA assay for Antigen Detection |
Reference
"Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2."
Nucleic Acids Res. 18:664-664(1990) [PubMed] [Europe PMC] [Abstract]
"Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site."
Proc. Natl. Acad. Sci. U.S.A. 87:9378-9382(1990) [PubMed] [Europe PMC] [Abstract]
"cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues."
DNA Cell Biol. 10:319-328(1991) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Nucleotide sequence analysis of the human fur gene."
Nucleic Acids Res. 17:7101-7102(1989) [PubMed] [Europe PMC] [Abstract]
"Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein."
EMBO J. 5:2197-2202(1986) [PubMed] [Europe PMC] [Abstract]
"A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells."
Biochem. Biophys. Res. Commun. 195:1019-1026(1993) [PubMed] [Europe PMC] [Abstract]
"A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation."
J. Biol. Chem. 270:26565-26569(1995) [PubMed] [Europe PMC] [Abstract]
"Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage."
J. Biol. Chem. 267:14304-14308(1992) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases."
Eur. J. Biochem. 222:255-266(1994) [PubMed] [Europe PMC] [Abstract]
"Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail."
EMBO J. 14:5869-5883(1995) [PubMed] [Europe PMC] [Abstract]
"PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic."
EMBO J. 20:2191-2201(2001) [PubMed] [Europe PMC] [Abstract]