G-Elongation Factor, Mitochondrial 1 (GFM1)

COXPD1; EFG; EFG1; EFGM; EGF1; GFM; hEFG1

SPN	U351
HGNC	13780
MGI	107339
PubMed	21986555
RGD	631396
UniProt	Q96RP9
Wiki	GFM1

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA.

Elongation factor G 1, mitochondrial is one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.

Reference

"Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and gfm, and mapping of GFM to human chromosome 3q25.1-q26.2."
Genomics 74:109-114(2001) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution."
Hum. Genet. 109:542-550(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression and characterization of isoform 1 of human mitochondrial elongation factor G."
Protein Expr. Purif. 37:368-376(2004) [PubMed] [Europe PMC] [Abstract]

"EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis."
Mol. Cell 35:502-510(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency."
N. Engl. J. Med. 351:2080-2086(2004) [PubMed] [Europe PMC] [Abstract]

"Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu."
Am. J. Hum. Genet. 80:44-58(2007) [PubMed] [Europe PMC] [Abstract]