Glyoxalase I (GLO1)

GLY-I; GLOD1; Glyoxalase Domain Containing 1; Lactoylglutathione lyase; Aldoketomutase; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase

SPN	U347
HGNC	4323
MGI	95742
PubMed	14641067
RGD	2702
UniProt	Q04760
Wiki	Glyoxalase_I

Glyoxalase I (EC 4.4.1.5) is a glutathione-binding protein involved in the detoxification of methylglyoxal, a byproduct of glycolysis. GLO1 and glyoxalase II (GLO2) catalyze successive steps in the pathway. GLO1 catalyzes condensation of methylglyoxal and reduced glutathione to form S-lactoyl-glutathione; GLO2 (hydroxyacyl glutathione hydrolase) converts the latter substance to D-lactic acid and reduced glutathione .The human enzyme showed 42% amino acid homology with bacterial Glo1. Northern blot analysis identified a 2.2-kb mRNA transcript in colon tissue. There was a 12-fold increase of the GLO1 transcript in colon carcinoma tissue compared to normal colon tissue from the same patient, and the authors concluded that GLO1 gene expression was induced in colon carcinoma.

Reference

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