Glutamate Carboxypeptidase II (GCPII)

FOLH1; PSM; FGCP; FOLH; GCP2; NAALAD1; PSMA; mGCP; NAALADase I; Prostate-specific membrane antigen; Folate Hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase

SPN	U336
HGNC	3788
MGI	1858193
PubMed	17684227
RGD	70963
UniProt	Q04609
Wiki	GCPII

Glutamate carboxypeptidase II is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.

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