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Histatin 3 (HTN3)

HIS2; HTN2; HTN5; Hst; PB; Histidine-rich protein 3; Basic histidine-rich protein

The primary protein encoded by HTN3 is histatin 3. Histatins are a family of small, histidine-rich, salivary proteins, encoded by at least two loci (HTN3 and HTN1). Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1(1) and HIS2(1) alleles, respectively. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity. Histatin 1 and histatin 2 are major wound-closing factors in human saliva.Histatin-3 1/24 (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, histatin-3 1/24 is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U314Hu01 Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies MU314Hu21 Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histatin 3 (HTN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histatin 3 (HTN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histatin 3 (HTN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histatin 3 (HTN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histatin 3 (HTN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histatin 3 (HTN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histatin 3 (HTN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histatin 3 (HTN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histatin 3 (HTN3) CLIA assay for Antigen Detection

Reference

"Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2)."
Biochem. Biophys. Res. Commun. 160:495-502(1989) [PubMed] [Europe PMC] [Abstract]

"Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence."
Biochem. Biophys. Res. Commun. 149:784-790(1987) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of human submandibular histatins."
Arch. Oral Biol. 35:137-143(1990) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family."
Mol. Biol. Evol. 10:497-511(1993) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant."
Hum. Mutat. 4:12-19(1994) [PubMed] [Europe PMC] [Abstract]

"Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans."
J. Biol. Chem. 263:7472-7477(1988) [PubMed] [Europe PMC] [Abstract]

"Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva."
Arch. Oral Biol. 35:415-419(1990) [PubMed] [Europe PMC] [Abstract]

"A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway."
J. Biol. Chem. 279:41436-41443(2004) [PubMed] [Europe PMC] [Abstract]

"Candidacidal activity of recombinant human salivary histatin-5 and variants."
Infect. Immun. 64:5000-5007(1996) [PubMed] [Europe PMC] [Abstract]

"Zinc and copper bind to unique sites of histatin 5."
FEBS Lett. 491:76-80(2001) [PubMed] [Europe PMC] [Abstract]

"Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease."
Infect. Immun. 69:1402-1408(2001) [PubMed] [Europe PMC] [Abstract]

"Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5."
J. Biol. Chem. 278:28553-28561(2003) [PubMed] [Europe PMC] [Abstract]

"Immunocytochemical localization of histatins in human salivary glands."
J. Histochem. Cytochem. 52:361-370(2004) [PubMed] [Europe PMC] [Abstract]

"Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland."
J. Proteome Res. 6:2472-2480(2007) [PubMed] [Europe PMC] [Abstract]

"Salivary peptidomics."
Expert Rev. Proteomics 7:709-721(2010) [PubMed] [Europe PMC] [Abstract]