Islet Cell Autoantigen 1 (ICA1)

ICA69; ICAp69; ICA-p69; 69 kDa islet cell autoantigen

SPN	U311
HGNC	5343
MGI	96391
PubMed	8162706
RGD	621465
UniProt	Q05084
Wiki	ICA1

Islet cell autoantigen 1, 69kDa, also known as ICA1 is a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules.

This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Islet Cell Autoantigen 1 expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.

Reference

"Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen."
J. Clin. Invest. 92:359-371(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes."
Biochim. Biophys. Acta 1227:101-104(1994) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity."
Genomics 38:382-391(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells."
J. Biol. Chem. 278:26166-26173(2003) [PubMed] [Europe PMC] [Abstract]