Lens Intrinsic Membrane Protein 2 (LIM2)

MP19; Lens Fiber Membrane Intrinsic Protein

SPN	U283
HGNC	6610
MGI	104698
PubMed	17251442
RGD	621482
UniProt	P55344
Wiki	LIM2

The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formation of cataracts, e.g., crystalline-gamma-1 (CRYG1). The second most abundant intrinsic membrane protein of the lens fiber cell is MP19, so named for major lens protein having a molecular weight of 19.5 kD. This protein appears to contain 4 transmembrane domains, is a substrate for cAMP-dependent protein kinase and protein kinase C, and binds with calmodulin. Taken together, these suggest that MP19 functions in some way as a junctional component, possibly involved with lens cell communication. It has been shown to be involved with cataractogenesis.

Reference

"The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis."
Curr. Eye Res. 12:1057-1065(1993) [PubMed] [Europe PMC] [Abstract]

"Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants."
Mol. Vis. 8:171-184(2002) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of an 18,000-dalton protein in mammalian lens fiber cell membranes."
J. Biol. Chem. 264:19967-19973(1989) [PubMed] [Europe PMC] [Abstract]

"A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family."
Am. J. Hum. Genet. 70:1363-1367(2002) [PubMed] [Europe PMC] [Abstract]