Lysyl Oxidase (LOX)

Protein-Lysine 6-Oxidase

SPN	U270
HGNC	6664
MGI	96817
PubMed	9524359
RGD	3015
UniProt	P28300
Wiki	LOX

Lysyl oxidase is a protein. Its inhibition can cause lathyrism, but at the same time, its upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous.Lysyl oxidase is an extracellular copper enzyme that catalyzes formation of aldehydes from lysine residues in collagen and elastin precursors.These aldehydes are highly reactive, and undergo spontaneous chemical reactions with other lysyl oxidase-derived aldehyde residues, or with unmodified lysine residues. This results in cross-linking collagen and elastin, which is essential for stabilization of collagen fibrils and for the integrity and elasticity of mature elastin.Complex cross-links are formed in collagen and in elastin that differ in structure.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U270Hu01	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	MU270Hu22	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	PU270Hu01	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	LU270Hu71	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	LU270Hu81	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	KEU270Hu	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U270Mu01	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	PU270Mu01	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	LU270Mu71	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	LU270Mu81	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	KEU270Mu	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	KEU270Ra	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Lysyl Oxidase (LOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Lysyl Oxidase (LOX)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Lysyl Oxidase (LOX)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Lysyl Oxidase (LOX)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Lysyl Oxidase (LOX)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Lysyl Oxidase (LOX)	CLIA assay for Antigen Detection

Reference

"Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2."
Genomics 11:508-516(1991) [PubMed] [Europe PMC] [Abstract]

"The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene)."
Matrix 12:242-248(1992) [PubMed] [Europe PMC] [Abstract]

"A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase."
J. Biol. Chem. 270:7176-7182(1995) [PubMed] [Europe PMC] [Abstract]

"Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene."
Mol. Cell. Biochem. 194:79-91(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the human lysyl oxidase gene."
Genomics 17:544-548(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human lysyl oxidase gene locus."
J. Biol. Chem. 267:14382-14387(1992) [PubMed] [Europe PMC] [Abstract]

"A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene."
Genomics 16:401-406(1993) [PubMed] [Europe PMC] [Abstract]