Uridine Cytidine Kinase 2 (UCK2)

UK; UMPK; Uridine Monophosphate Kinase; Cytidine monophosphokinase 2; Testis-specific protein TSA903; Uridine monophosphokinase 2

SPN	U266
HGNC	12562
MGI	1931744
PubMed	23462292
RGD	620742
UniProt	Q9BZX2
Wiki	UCK2

Uridine-cytidine kinase 2 is an enzyme catalyzes the phosphorylation of uridine monophosphate to uridine diphosphate. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B. Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.

Reference

"Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method."
Genomics 36:316-319(1996) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases."
Mol. Pharmacol. 59:1181-1186(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells."
Int. J. Mol. Med. 8:273-278(2001) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase."
Structure 12:751-764(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative."
Acta Crystallogr. D 61:278-284(2005) [PubMed] [Europe PMC] [Abstract]