Ubiquinol Cytochrome C Reductase Binding Protein (UQCRB)

QP-C; QPC; UQBC; UQBP; UQPC; Ubiquinol-Cytochrome C Reductase,Complex III Subunit VI; Ubiquinol-cytochrome c reductase complex 14 kDa protein

SPN	U261
HGNC	12582
MGI	3646665
PubMed	23454382
RGD	1585163
UniProt	P14927
Wiki	UQCRB

UQCRB is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR,Complex III or Cytochrome bc1 complex), Subunit 7 was identified as a Q-binding protein by photo-labeling with a ubiquinone analog (subsequent structures show it to be exposed to the lipid phase but not involved in either Q-binding site). Subunits 6 and 7 reverse position on going from Laemli gels to Weber&Osborne gels, and one might suspect the name "Q-binding protein" arose from confusion with subunit 7. I have been told however that this is not the case, and both proteins were separately identified as Q-binding proteins. Genome anotators improved the situation by naming its gene "UQCR binding", UQCRB.

Reference

"Cloning and sequencing of a cDNA for human mitochondrial ubiquinone-binding protein of complex III."
Biochem. Biophys. Res. Commun. 156:987-994(1988) [PubMed] [Europe PMC] [Abstract]

"Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain."
Biochem. Biophys. Res. Commun. 161:371-378(1989) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein."
J. Biol. Chem. 265:8159-8163(1990) [PubMed] [Europe PMC] [Abstract]

"A deletion in the human QP-C gene causes a complex III deficiency resulting in hypoglycaemia and lactic acidosis."
Hum. Genet. 113:118-122(2003) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]