Vasoactive Intestinal Peptide Receptor 1 (VIPR1)

HVR1; PACAP-R-2; RDC1; VAPC1; VIPR; VIRG; VPAC1; Pituitary adenylate cyclase-activating polypeptide type II receptor

SPN	U255
HGNC	12694
MGI	109272
PubMed	20922191
RGD	3961
UniProt	P32241
Wiki	VIPR1

Vasoactive intestinal peptide receptor 1 is expressed in the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis .
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate

Reference

"Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor."
Biochem. Biophys. Res. Commun. 193:546-553(1993) [PubMed] [Europe PMC] [Abstract]

"Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains."
Biochem. Biophys. Res. Commun. 200:769-776(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor."
Cell. Signal. 6:321-333(1994) [PubMed] [Europe PMC] [Abstract]

"Highly conserved aspartate 68, tryptophan 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP."
Biochem. Biophys. Res. Commun. 206:246-252(1995) [PubMed] [Europe PMC] [Abstract]

"Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals."
J. Clin. Immunol. 16:21-30(1996) [PubMed] [Europe PMC] [Abstract]

"Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production."
Ann. N. Y. Acad. Sci. 865:259-265(1998) [PubMed] [Europe PMC] [Abstract]

"Dual, HLA-B27 subtype-dependent conformation of a self-peptide."
J. Exp. Med. 199:271-281(2004) [PubMed] [Europe PMC] [Abstract]

"Citrullination-dependent differential presentation of a self-peptide by HLA-B27 subtypes."
J. Biol. Chem. 283:27189-27199(2008) [PubMed] [Europe PMC] [Abstract]