Valosin Containing Protein (VCP)
IBMPFD; p97; TERA; Transitional Endoplasmic Reticulum ATPase; 15S Mg(2+)-ATPase p97 subunit
VCP is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
Clathrin is a structural protein found in coated pits and vesicles, organelles which are important in membrane trafficking functions such as endocytosis and Golgi sorting. A 100-kD protein, designated valosin-containing protein or VCP by early investigators, is a structural protein complexed with clathrin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Hu01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Hu01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Hu01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Hu01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Hu01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Mu01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Mu01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Mu01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Mu01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Mu01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Ra01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Ra01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Ra01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Ra01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Ra01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Ca01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Ca01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Ca01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Ca01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Ca01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Po01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Po01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Po01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Po01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Po01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Bo01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Bo01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Bo01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Bo01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Bo01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Rb01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Rb01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Rb01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Rb01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Rb01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU250Mo01 | Recombinant Valosin Containing Protein (VCP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU250Mo01 | Monoclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IP. |
| PAU250Mo01 | Polyclonal Antibody to Valosin Containing Protein (VCP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU250Mo01 | CLIA Kit for Valosin Containing Protein (VCP) | CLIA assay for Antigen Detection |
| ELU250Mo01 | ELISA Kit for Valosin Containing Protein (VCP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
, Submitted (NOV-2005) to UniProtKB
"Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein."
Nature 365:459-462(1993) [PubMed] [Europe PMC] [Abstract]