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Xanthine Dehydrogenase (XDH)

XO; XOR; XOD; Xanthine Oxidase; NAD+-Xanthine Dehydrogenase; Xanthine-NAD+ Oxidoreductase; Xanthine/NAD+ Oxidoreductase; Xanthine Oxidoreductase

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.
The three substrates of this enzyme are xanthine, NAD+, and H2O, whereas its three products are urate, NADH, and H+.This enzyme belongs to the family of oxidoreductases, to be specific, those acting on CH or CH2 group with NAD+ or NADP+ as acceptor.Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U243Hu01 Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies MU243Hu22 Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
PU243Hu01 Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits KEU243Hu ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
KCU243Hu CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U243Mu01 Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
PU243Mu01 Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits KEU243Mu ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
KCU243Mu CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U243Ra01 Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies MU243Ra21 Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
PU243Ra01 Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits KEU243Ra ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U243Bo01 Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies MU243Bo21 Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
PU243Bo01 Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits KEU243Bo ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
KCU243Bo CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Xanthine Dehydrogenase (XDH) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Xanthine Dehydrogenase (XDH) Bioactivity
Antibodies NONE Monoclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Xanthine Dehydrogenase (XDH) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Xanthine Dehydrogenase (XDH) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Xanthine Dehydrogenase (XDH) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Xanthine Dehydrogenase (XDH) CLIA assay for Antigen Detection

Reference

"Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene."
Gene 133:279-284(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, tissue expression of human xanthine dehydrogenase."
Biochem. Biophys. Res. Commun. 199:998-1004(1994) [PubMed] [Europe PMC] [Abstract]

Erratum
Biochem. Biophys. Res. Commun. 215:429-429(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression in vitro of human xanthine dehydrogenase/oxidase."
Biochem. J. 315:235-239(1996) [PubMed] [Europe PMC] [Abstract]

"Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria."
J. Clin. Invest. 99:2391-2397(1997) [PubMed] [Europe PMC] [Abstract]

"XDH gene mutation is the underlying cause of classical xanthinuria: a second report."
Kidney Int. 57:2215-2220(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate."
J. Biochem. 141:513-524(2007) [PubMed] [Europe PMC] [Abstract]

"Human milk xanthine dehydrogenase is incompletely converted to the oxidase form in the absence of proteolysis. A structural explanation."
Submitted (FEB-2009) to the PDB data bank

"Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria."
Hum. Genet. 108:279-283(2001) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria."
Nephrol. Dial. Transplant. 18:2278-2283(2003) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]