Macrophage Receptor With Collagenous Structure (MARCO)

SCARA2; Scavenger Receptor Class A,Member 2

SPN	U237
HGNC	6895
MGI	1309998
PubMed	15263032
RGD	1589662
UniProt	Q9UEW3

Macrophage receptor MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied.

Reference

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