Myeloid Cell Leukemia Sequence 1, Bcl2 Related (MCL1)

EAT; MCL1L; MCL1S; BCL2L3; TM; Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; mcl1/EAT

SPN	U236
HGNC	6943
MGI	101769
PubMed	15474972
RGD	620525
UniProt	Q07820
Wiki	MCL1

Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.

Reference

"MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2."
Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993) [PubMed] [Europe PMC] [Abstract]

"Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3."
Cell Struct. Funct. 21:143-150(1996) [PubMed] [Europe PMC] [Abstract]

"Functional analysis of the human MCL-1 gene."
Cell. Mol. Life Sci. 57:684-691(2000) [PubMed] [Europe PMC] [Abstract]

"Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death."
J. Biol. Chem. 275:22136-22146(2000) [PubMed] [Europe PMC] [Abstract]

"MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain."
J. Biol. Chem. 275:25255-25261(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Acute myeloid leukemia possessing jumping translocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions."
Leuk. Res. 24:73-77(2000) [PubMed] [Europe PMC] [Abstract]

"Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage."
Oncogene 23:4818-4827(2004) [PubMed] [Europe PMC] [Abstract]

"Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response."
Mol. Cell. Biol. 18:4883-4898(1998) [PubMed] [Europe PMC] [Abstract]

"Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone."
J. Biol. Chem. 277:37430-37438(2002) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress."
J. Biol. Chem. 277:43730-43734(2002) [PubMed] [Europe PMC] [Abstract]

"Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex."
Nat. Cell Biol. 6:443-450(2004) [PubMed] [Europe PMC] [Abstract]

"MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol."
Oncogene 23:5301-5315(2004) [PubMed] [Europe PMC] [Abstract]

"Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis."
Cell 121:1085-1095(2005) [PubMed] [Europe PMC] [Abstract]

"Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1."
Mol. Cell 21:749-760(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1."
PLoS ONE 7:E45088-E45088(2012) [PubMed] [Europe PMC] [Abstract]

"Human Bop is a novel BH3-only member of the Bcl-2 protein family."
Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the degradation of Mcl-1 induced by BH3 domains."
Proc. Natl. Acad. Sci. U.S.A. 104:6217-6222(2007) [PubMed] [Europe PMC] [Abstract]

"The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer."
Nat. Chem. Biol. 6:595-601(2010) [PubMed] [Europe PMC] [Abstract]

"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]