Metastasis Associated Protein 1 (MTA1)

SPN	U221
HGNC	7410
MGI	2150037
PubMed	12650603
RGD	621018
UniProt	Q13330
Wiki	MTA1

Metastasis-associated protein MTA1 is a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA.

Reference

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J. Biol. Chem. 269:22958-22963(1994) [PubMed] [Europe PMC] [Abstract]

"Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines."
Gene 159:97-104(1995) [PubMed] [Europe PMC] [Abstract]

"A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm."
Nature 418:654-657(2002) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities."
Mol. Cell 2:851-861(1998) [PubMed] [Europe PMC] [Abstract]

"Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator."
Mol. Cell. Biol. 24:6581-6591(2004) [PubMed] [Europe PMC] [Abstract]

"Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase."
Oncogene 23:4422-4429(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"MTA1, a transcriptional activator of breast cancer amplified sequence 3."
Proc. Natl. Acad. Sci. U.S.A. 103:6670-6675(2006) [PubMed] [Europe PMC] [Abstract]

Erratum
Proc. Natl. Acad. Sci. U.S.A. 110:4147-4148(2013)

"Identification of Pax5 as a target of MTA1 in B-cell lymphomas."
Cancer Res. 67:7132-7138(2007) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene."
Oncogene 27:1971-1980(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"MTA1 coregulator regulates p53 stability and function."
J. Biol. Chem. 284:34545-34552(2009) [PubMed] [Europe PMC] [Abstract]

"E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1."
Proc. Natl. Acad. Sci. U.S.A. 106:17493-17498(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor."
Cancer Res. 70:6649-6658(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."
J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer."
Cancer Res. 72:387-394(2012) [PubMed] [Europe PMC] [Abstract]

"RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene."
Oncogene 32:3711-3721(2013) [PubMed] [Europe PMC] [Abstract]

"Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."
Cancer Res. 74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The subcellular distribution and function of MTA1 in cancer differentiation."
Oncotarget 5:5153-5164(2014) [PubMed] [Europe PMC] [Abstract]