Metadherin (MTDH)

3D3; AEG1; LYRIC; Astrocyte elevated gene-1 protein; Lysine-rich CEACAM1 co-isolated protein; Metastasis adhesion protein

SPN	U220
HGNC	29608
MGI	1914404
PubMed	15093543
RGD	620992
UniProt	Q86UE4
Wiki	MTDH

Elevated expression of the metastasis gene metadherin (MTDH), which is overexpressed in more than 40% of breast cancers, is associated with poor clinical outcomes. MTDH has a dual role in promoting metastatic seeding and enhancing chemoresistance.

MTDH is therefore a potential therapeutic target for enhancing chemotherapy and reducing metastasis. Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

Reference

"3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus."
Exp. Cell Res. 294:94-105(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells."
Exp. Cell Res. 300:134-148(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1."
Gene 353:8-15(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Gene expression profiling predicts clinical outcome of breast cancer."
Nature 415:530-536(2002) [PubMed] [Europe PMC] [Abstract]

"Metadherin, a cell surface protein in breast tumors that mediates lung metastasis."
Cancer Cell 5:365-374(2004) [PubMed] [Europe PMC] [Abstract]

"Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis."
Cancer Res. 66:1509-1516(2006) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells."
Biochem. Biophys. Res. Commun. 371:333-338(2008) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1."
Cancer Res. 68:1478-1484(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer."
Cancer Cell 15:9-20(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]