Metal Regulatory Transcription Factor 1 (MTF1)

ZRF; MRE-binding transcription factor

SPN	U218
HGNC	7428
MGI	101786
PubMed	15226267
RGD	1308956
UniProt	Q14872
Wiki	MTF1

Metal regulatory transcription factor 1 is a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).

The human protein has 753 amino acids with 93% amino acid sequence identity to the mouse protein and has an extension of 78 amino acids at the C terminus without counterpart in the mouse. In the 2 species the factor has the same overall structure, including 6 zinc fingers in the DNA binding domain.

Reference

"Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1."
Nucleic Acids Res. 22:3167-3173(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]