Mitochondrial Tumor Suppressor 1 (MTUS1)

ATIP; MP44; MTSG1; ATIP1; ATBP; Microtubule Associated Tumor Suppressor 1; AT2 Receptor-Interacting Protein; Angiotensin-II type 2 receptor-interacting protein

SPN	U216
HGNC	29789
MGI	2142572
PubMed	19956880
RGD	631381
UniProt	Q63HJ6
Wiki	MTUS1

Mitochondrial tumor suppressor 1 is a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC).

Reference

"Molecular cloning and characterization of two novel genes on chromosome 8p21.3."
J. Hum. Genet. 45:12-17(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of a new tumor suppressor gene located at chromosome 8p21.3-22."
FASEB J. 17:1180-1182(2003) [PubMed] [Europe PMC] [Abstract]

"Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."
J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]

"Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival."
Cancer 104:2417-2429(2005) [PubMed] [Europe PMC] [Abstract]

"Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP."
Gene 380:127-136(2006) [PubMed] [Europe PMC] [Abstract]

"Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon."
Oncol. Rep. 16:747-754(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis."
PLoS ONE 4:E7239-E7239(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma."
Mol. Cell. Endocrinol. 252:207-215(2006) [PubMed] [Europe PMC] [Abstract]

"Genomic assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck squamous cell carcinoma."
Cancer Genet. Cytogenet. 176:100-106(2007) [PubMed] [Europe PMC] [Abstract]