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Monoamine Oxidase B (MAOB)

MAO-B; Amine oxidase [flavin-containing] B

Monoamine oxidase B, is a protein belongs to the flavin monoamine oxidase family. It is an enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.Edmondson et al. described structural features of the human enzyme: it has a hydrophobic bipartite elongated cavity that (for the "open" conformation) occupies a combined volume close to 700 Å3. hMAO-A has a single cavity that exhibits a rounder shape and is larger in volume than the "substrate cavity" of hMAO-B.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U208Mu01 Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits KEU208Mu ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Monoamine Oxidase B (MAOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Monoamine Oxidase B (MAOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Monoamine Oxidase B (MAOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Monoamine Oxidase B (MAOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Monoamine Oxidase B (MAOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Monoamine Oxidase B (MAOB) CLIA assay for Antigen Detection

Reference

"Human monoamine oxidase A and B genes exhibit identical exon-intron organization."
Proc. Natl. Acad. Sci. U.S.A. 88:3637-3641(1991) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties."
Proc. Natl. Acad. Sci. U.S.A. 85:4934-4938(1988) [PubMed] [Europe PMC] [Abstract]

"The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical."
J. Neurochem. 61:187-190(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"Promoter organization and activity of human monoamine oxidase (MAO) A and B genes."
J. Neurosci. 12:4437-4446(1992) [PubMed] [Europe PMC] [Abstract]

"High-level expression of human liver monoamine oxidase B in Pichia pastoris."
Protein Expr. Purif. 20:334-345(2000) [PubMed] [Europe PMC] [Abstract]

"Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis."
Eur. J. Biochem. 236:996-1002(1996) [PubMed] [Europe PMC] [Abstract]

"Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines."
Mol. Pharmacol. 43:888-893(1993) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders."
Nat. Struct. Biol. 9:22-26(2002) [PubMed] [Europe PMC] [Abstract]

"Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures."
Proc. Natl. Acad. Sci. U.S.A. 100:9750-9755(2003) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class."
J. Med. Chem. 47:1767-1774(2004) [PubMed] [Europe PMC] [Abstract]

"Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors."
J. Biol. Chem. 280:15761-15766(2005) [PubMed] [Europe PMC] [Abstract]

"Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis."
J. Med. Chem. 48:8148-8154(2005) [PubMed] [Europe PMC] [Abstract]