Myocyte Specific Enhancer Factor 2A (MEF2A)

MEF2-A; ADCAD1; RSRFC4; RSRFC9; MADS Box Transcription Enhancer Factor 2,Polypeptide A; Serum response factor-like protein 1

SPN	U204
HGNC	6993
MGI	99532
PubMed	15841183
UniProt	Q02078
Wiki	MEF2A

Myocyte-specific enhancer factor 2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD, myogenin, MYF5, and MRF4 are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes.

Reference

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