Call Now

Neurochondrin (NCDN)

Norbin

Neurochondrin is a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, and fetal brain.
According to one study, Norbin can modulate signaling activty and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Hu01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Hu01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Hu01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Hu01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Hu01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Mu01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Mu01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Mu01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Mu01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Mu01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Ra01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Ra01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Ra01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Ra01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Ra01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Ca01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Ca01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Ca01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Ca01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Ca01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Po01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Po01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Po01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Po01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Po01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Bo01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Bo01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Bo01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Bo01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Bo01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Rb01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Rb01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Rb01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Rb01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Rb01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU197Mo01 Recombinant Neurochondrin (NCDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU197Mo01 Monoclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IP.
PAU197Mo01 Polyclonal Antibody to Neurochondrin (NCDN) WB; IHC; ICC; IF.
Assay Kits CLU197Mo01 CLIA Kit for Neurochondrin (NCDN) CLIA assay for Antigen Detection
ELU197Mo01 ELISA Kit for Neurochondrin (NCDN) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and expression of human neurochondrin-1 and -2."
Biochim. Biophys. Acta 1446:397-402(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Biochim. Biophys. Acta 1490:367-368(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]

"Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization."
J. Biol. Chem. 281:32496-32507(2006) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]