Nucleophosmin (NPM)

B23; NPM1; Nucleolar Phosphoprotein B23; Numatrin; Nucleophosmin/Nucleoplasmin Family,Member 1; Nucleolar protein NO38

SPN	U188
HGNC	7910
MGI	3647121
PubMed	16794633
RGD	3192
UniProt	P06748
Wiki	NPM1

NPM1 is associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may be involved in the assembly and/or transport of ribosome. Its regulation through SUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions. It is located in nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. The protein is phosphorylated.

Chromosomal aberrations involving NPM1 were found in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acute myelogenous leukemia.It has been found in the cytoplasm in patients with primary acute myelogenous leukemia.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Hu01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Hu01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Hu01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Hu01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Hu01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Mu01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Mu01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Mu01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Mu01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Mu01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Ra01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Ra01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Ra01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Ra01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Ra01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Ca01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Ca01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Ca01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Ca01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Ca01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Po01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Po01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Po01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Po01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Po01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Bo01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Bo01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Bo01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Bo01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Bo01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Rb01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Rb01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Rb01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Rb01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Rb01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU188Mo01	Recombinant Nucleophosmin (NPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU188Mo01	Monoclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IP.
Antibodies	PAU188Mo01	Polyclonal Antibody to Nucleophosmin (NPM)	WB; IHC; ICC; IF.
Assay Kits	CLU188Mo01	CLIA Kit for Nucleophosmin (NPM)	CLIA assay for Antigen Detection
Assay Kits	ELU188Mo01	ELISA Kit for Nucleophosmin (NPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth."
Biochemistry 28:1033-1039(1989) [PubMed] [Europe PMC] [Abstract]

"The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23."
Biochem. Biophys. Res. Commun. 163:72-78(1989) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin."
Biochem. Biophys. Res. Commun. 164:176-184(1989) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region."
Nucleic Acids Res. 25:1225-1232(1997) [PubMed] [Europe PMC] [Abstract]

"Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype."
N. Engl. J. Med. 352:254-266(2005) [PubMed] [Europe PMC] [Abstract]

"Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia."
Lancet Oncol. 7:350-352(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion."
Blood 87:882-886(1996) [PubMed] [Europe PMC] [Abstract]

"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma."
Science 263:1281-1284(1994) [PubMed] [Europe PMC] [Abstract]

"Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)."
Proc. Natl. Acad. Sci. U.S.A. 93:4181-4186(1996) [PubMed] [Europe PMC] [Abstract]