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Natriuretic Peptide Receptor 1 (NPR1)

ANPRA; ANPa; GUC2A; GUCY2A; NPR-A; Guanylate Cyclase A; Atrionatriuretic Peptide Receptor A; Atrial natriuretic peptide receptor type A

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides.The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2).  NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP )

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Hu01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Hu01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Hu01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Hu01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Hu01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Mu01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Mu01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Mu01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Mu01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Mu01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Ra01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Ra01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Ra01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Ra01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Ra01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Ca01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Ca01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Ca01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Ca01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Ca01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Po01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Po01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Po01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Po01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Po01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Bo01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Bo01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Bo01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Bo01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Bo01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Rb01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Rb01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Rb01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Rb01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Rb01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU187Mo01 Recombinant Natriuretic Peptide Receptor 1 (NPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU187Mo01 Monoclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IP.
PAU187Mo01 Polyclonal Antibody to Natriuretic Peptide Receptor 1 (NPR1) WB; IHC; ICC; IF.
Assay Kits CLU187Mo01 CLIA Kit for Natriuretic Peptide Receptor 1 (NPR1) CLIA assay for Antigen Detection
ELU187Mo01 ELISA Kit for Natriuretic Peptide Receptor 1 (NPR1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction."
EMBO J. 8:1377-1384(1989) [PubMed] [Europe PMC] [Abstract]

"Organization of the human natriuretic peptide receptor A gene."
Biochem. Biophys. Res. Commun. 246:736-739(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of mRNA for atrial natriuretic peptide receptor guanylate cyclase (ANPRA) in human retina."
Cell. Mol. Neurobiol. 14:1-7(1994) [PubMed] [Europe PMC] [Abstract]

"Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
J. Biol. Chem. 266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]

"Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]

"Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B."
Biochemistry 49:10137-10145(2010) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]