Nuclear Respiratory Factor 1 (NRF1)

ALPHA-PAL; EWG; Alpha Palindromic-Binding Protein

SPN	U183
HGNC	7996
MGI	1332235
PubMed	20805060
RGD	1304603
UniProt	Q16656
Wiki	NRF1

Nuclear respiratory factor 1 is a phosphorylated nuclear protein with a bZIP domain. This protein homodimerizes and functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized.Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.

Reference

"NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators."
Genes Dev. 7:2431-2445(1993) [PubMed] [Europe PMC] [Abstract]

"A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development."
J. Biol. Chem. 269:18921-18930(1994) [PubMed] [Europe PMC] [Abstract]

"Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1."
J. Biol. Chem. 270:18019-18025(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The pre-mRNA of nuclear respiratory factor 1, a regulator of mitochondrial biogenesis, is alternatively spliced in human tissues and cell lines."
Hum. Mol. Genet. 4:1591-1596(1995) [PubMed] [Europe PMC] [Abstract]

"Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding."
J. Biol. Chem. 272:18732-18739(1997) [PubMed] [Europe PMC] [Abstract]

"Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells."
Mol. Cell. Biol. 21:3738-3749(2001) [PubMed] [Europe PMC] [Abstract]

"PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."
Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]