Neurotensin Receptor 2 (NTSR2)

NTR2; Levocabastine-sensitive neurotensin receptor

SPN	U176
HGNC	8040
MGI	108018
PubMed	11687289
RGD	70962
UniProt	O95665
Wiki	NTSR2

Neurotensin receptor type 2 is a protein belongs to the G protein-coupled receptor family that activate a phosphatidylinositol calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor.

However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.The extent of this transcript is supported by transcript alignments.

Reference

"Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells."
Eur. J. Pharmacol. 360:265-272(1998) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."
Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]