2',5'-Oligoadenylate Synthetase 1 (OAS1)

2,5OAS1; 25-OAS1; OAS1; IFI-4; OIAS; OIASI; E18/E16

SPN	U169
HGNC	8086
MGI	97429
PubMed	15855350
RGD	621760
UniProt	P00973
Wiki	OAS1

2'-5'-oligoadenylate synthetase 1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection.

The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Reference

"Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences."
EMBO J. 4:2249-2256(1985) [PubMed] [Europe PMC] [Abstract]

"Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon."
FEBS Lett. 196:113-120(1986) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase."
J. Biochem. 99:1455-1464(1986) [PubMed] [Europe PMC] [Abstract]

"Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships."
J. Biol. Chem. 266:15293-15299(1991) [PubMed] [Europe PMC] [Abstract]

"The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."
J. Mol. Evol. 63:562-576(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"New inducers revealed by the promoter sequence analysis of two interferon-activated human genes."
Eur. J. Biochem. 169:313-321(1987) [PubMed] [Europe PMC] [Abstract]

"Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene."
Mol. Cell. Biol. 7:4498-4504(1987) [PubMed] [Europe PMC] [Abstract]

"Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene."
EMBO J. 7:751-759(1988) [PubMed] [Europe PMC] [Abstract]

"Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure."
EMBO J. 4:1761-1768(1985) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells."
Proc. Natl. Acad. Sci. U.S.A. 80:4904-4908(1983) [PubMed] [Europe PMC] [Abstract]

"Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein."
J. Biol. Chem. 272:33220-33226(1997) [PubMed] [Europe PMC] [Abstract]

"The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases."
J. Biol. Chem. 274:25535-25542(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family."
Nucleic Acids Res. 31:3166-3173(2003) [PubMed] [Europe PMC] [Abstract]

"The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation."
Biochimie 89:779-788(2007) [PubMed] [Europe PMC] [Abstract]

"The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain."
J. Gen. Virol. 89:2767-2772(2008) [PubMed] [Europe PMC] [Abstract]

"Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection."
J. Immunol. 183:8035-8043(2009) [PubMed] [Europe PMC] [Abstract]

"Differential regulation of the OASL and OAS1 genes in response to viral infections."
J. Interferon Cytokine Res. 29:199-207(2009) [PubMed] [Europe PMC] [Abstract]

"Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria."
J. Mol. Evol. 69:612-624(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."
J. Interferon Cytokine Res. 31:41-47(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1."
Proc. Natl. Acad. Sci. U.S.A. 110:1652-1657(2013) [PubMed] [Europe PMC] [Abstract]