Peptidyl Arginine Deiminase Type I (PADI1)

PDI; PAD1; HPAD10; PDI1; Peptidylarginine Deiminase Type I; Protein-Arginine Deiminase Type-1; hPAD-Colony 10

SPN	U146
HGNC	18367
MGI	1338893
PubMed	17851584
RGD	3287
UniProt	Q9ULC6
Wiki	PADI1

Peptidyl arginine deiminase, type I, also known as PADI1, is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns.

The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.

Reference

"cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I."
Biochem. J. 370:167-174(2003) [PubMed] [Europe PMC] [Abstract]

"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]