Phosphomannomutase 1 (PMM1)
Sec53; PMMH-22; Brain Glucose-1,6-Bisphosphatase
Phosphomannomutase 1 is an enzyme encoded by the PMM1 gene.Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins.
The deduced 262-amino acid protein has a predicted molecular mass of 29 kD and shares 54% sequence identity with yeast phosphomannomutase. Expression of the human cDNA in Escherichia coli yielded an active phosphomannomutase that was purified to homogeneity.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Hu01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Hu01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Hu01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Hu01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Hu01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Mu01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Mu01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Mu01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Mu01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Mu01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Ra01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Ra01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Ra01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Ra01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Ra01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Ca01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Ca01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Ca01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Ca01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Ca01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Po01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Po01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Po01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Po01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Po01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Bo01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Bo01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Bo01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Bo01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Bo01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Rb01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Rb01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Rb01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Rb01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Rb01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU128Mo01 | Recombinant Phosphomannomutase 1 (PMM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU128Mo01 | Monoclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IP. |
| PAU128Mo01 | Polyclonal Antibody to Phosphomannomutase 1 (PMM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU128Mo01 | CLIA Kit for Phosphomannomutase 1 (PMM1) | CLIA assay for Antigen Detection |
| ELU128Mo01 | ELISA Kit for Phosphomannomutase 1 (PMM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13."
Genomics 40:41-47(1997) [PubMed] [Europe PMC] [Abstract]
"Isolation of the human phosphomannomutase gene (PMM1) and assignment to chromosome 22q13."
Genomics 39:416-417(1997) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a."
J. Biol. Chem. 281:14918-14926(2006) [PubMed] [Europe PMC] [Abstract]