Platelet Activating Factor Receptor (PAFR)

PTAFR

SPN	U104
HGNC	9582
MGI	106066
PubMed	16721373
RGD	61897
UniProt	P25105
Wiki	PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.The PAF receptor shows structural characteristics of the rhodopsin gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.

PTAFR has 2 N-glycosylation sites, but unlike other rhodopsin family members, there is no N-glycosylation site in the N-terminal segment. Transfection of PTAFR into COS-7 cells resulted in expression of the receptor with an extracellular N terminus.

Reference

"Characterization of a human cDNA that encodes a functional receptor for platelet activating factor."
Biochem. Biophys. Res. Commun. 180:105-111(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of platelet-activating factor receptor from human leukocytes."
J. Biol. Chem. 266:20400-20405(1991) [PubMed] [Europe PMC] [Abstract]

"The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog."
J. Biol. Chem. 267:9101-9106(1992) [PubMed] [Europe PMC] [Abstract]

"The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1."
Genomics 13:832-834(1992) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart."
Biochem. Biophys. Res. Commun. 189:617-624(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region."
Am. J. Respir. Cell Mol. Biol. 8:240-244(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation."
J. Immunol. 176:7039-7050(2006) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)